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They followed traditional anchor-based estimation methodology, using the Clinical Global Impression of Improvement (CGI-I) as the anchor measure, producing an estimate of a 5-point worsening (a mean change of 4.63 in patients rated as Minimally worse and a cut score of 4.5 using a Receiver Operating Characteristic curve) in an early PD population (Hoehn and Yahr Stage 12) 16

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is indicated for chronic weight management in adults as an adjunct to a reduced calorie diet and increased physical activity

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