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The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death

For the characterization of time-to-onset distribution patterns, we employed robust statistical descriptors, specifically the median value accompanied by the interquartile range (IQR), to account for potential distributional skewness and outlier effects

and importantly, some real uncertainty about different ways things could possibly go

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In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%