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Derived from hormone-related peptide frameworks, it has been examined for its effects on multi-receptor metabolic signaling processes involving GLP-1, GIP, and glucagon receptor pathways

This is the pharmacological basis for CagriSema : in REDEFINE 1, the combination produced 20.4% mean weight loss versus 11.8% for cagrilintide alone and 14.9% for semaglutide alone

doi: 10.1093/pm/pnv029

Published findings describe effects on genes associated with antioxidant response (Nrf2 pathway), DNA repair mechanisms, ubiquitin-proteasome pathway components, and inflammatory signaling cascades

Moreover, no side effects were found in these studies [6, 7, 8, 9]