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Moreover, co-administering NF-B inhibitor caffeic acid phenethyl ester (CAPE) with ALC also increased PPAR expression significantly and decreased NF-B and NLRP3 inflammasome

Long-term studies in mice show that Epithalon administration significantly extended maximum lifespan by 12.3% and increased the lifespan of the last 10% of survivors by 13.3% compared to control groups, while showing no adverse effects on body weight or food consumption

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2021. NNMT inhibition reduces obesity and diabetes risk

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