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The SELECT trial, published in 2023, additionally demonstrated that semaglutide reduces the risk of major cardiovascular events in adults with obesity and established cardiovascular disease suggesting cardiovascular benefit that extends beyond weight loss alone

Cardiovasc Toxicol 16:9099 Wiedemann F, Siemen D, Mawrin C, Horn T, Dietzmann K (2006) The neurotrophin receptor TrkB is colocalized to mitochondrial membranes

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Patients or caregivers should be instructed thoroughly on how to prepare the injection