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[58] Medical uses [edit] Treatment of deficiency [edit] Severe vitamin B 12 deficiency is initially corrected with daily intramuscular injections of 1000 g of the vitamin, followed by maintenance via monthly injections of the same amount or daily oral dosing of 1000 g

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10.1016/s1474-4422(14)70129-2 114 MiyazakiK.MasamotoK.MorimotoN.KurataT.MimotoT.ObataT.et al

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This suggests central production deterioration together with reduced gonadal sensitivity to LH and increased peripheral androgen degradation by their conversion to estrogens (207, 208)