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While serum amylase was determined in all groups in all intervals, AST, ALT, total bilirubin, direct and indirect, creatinine, urea and platelet count was assessed at 024 h of the application-sacrifice period

Its preservatives and sterile integrity decrease with time and this may affect safety

Topically yes

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The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity