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Actions of VIP in the body include: Vasodilation to assist in blood pressure regulation, GI tract epithelial cell secretion and blood flow increasing water and electrolytes in the GI tract, relaxation of intestinal smooth muscle, exerting a positive effect on hypothalamic kisspeptin neurons, hormone balancing, and aromatase inhibiting effect corrects estradiol, 25-OH Vitamin D, and testosterone in males, downregulation of th1 responses and controlling cytokine responses to restore immunoregulation, especially following infections by intracellular bacteria and viruses

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10.1126/science.1171498 Science 134 OkamotoK.BoschM.HayashiY

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cGAS-STING senses cytosolic double-stranded DNA and triggers an innate immune response through type I interferons