constipation while on glp 1 with GLP-1s: It's Common, and It's Manageable!: Women's Health Specialists, PLLC: OBGYNs GLP-1 Constipation Relief: 7 Strategies

Preclinical studies on bone specifically have shown consistent positive results

The catch is that the effect requires consistent, high-dose exposure, fades when treatment stops, and works very unevenly between individuals

Pretreatment with each examined GLP-1 analogs, including GLP-1(736), liraglutide, and exendin-4, led to significantly reduced Ca 2+ responses (by 53.8%, 58.1%, and 72.2%, respectively)

Shi, Z., & Puyo, C

More importantly, carriers of the rare variant R19X had lower incidence of coronary artery calcification and lower Framingham 10 year CAD risk [5]

Many overlook the role C-rating plays in reducing this effect