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The orally active PK activator mitapivat is the first approved therapeutic agent that is clinically beneficial for effective treatment of patients with PK deficiency (15, 16)

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Original studies were prioritized when they directly examined how amino acid metabolic pathways regulate macrophage polarization, inflammatory function, or disease-associated immune phenotypes in in vitro systems, animal models, or human samples

The identified alterations offer a deeper understanding of the biochemical environment associated with ischemic heart disease

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