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15-24% at diabetes doses), vomiting, diarrhea, constipation, and abdominal discomfort, which may be difficult to distinguish from neurogenic bowel dysfunction in MS patients [11] [3] Fatigue : Reported in clinical trials and potentially additive to MS-related fatigue, one of the most disabling MS symptoms Dizziness : May occur due to blood pressure changes or dehydration, overlapping with MS-related balance and vestibular symptoms Weight loss induced by tirzepatidewhile therapeutically beneficial for metabolic healthrequires monitoring in MS patients, as unintentional or excessive weight loss could affect mobility, muscle strength, and overall functional status

doi: 10.1016/S1474-4422(15)00141-6 51 ZhengMWangP

Participants completed original and adapted forms of validated assessments (see Supplemental document)

Retatrutide is a triple receptor agonist with no clearcut plateau