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Semaglutide was recently approved as a treatment for the prevention of heart attacks, and preliminary studies suggest that tirzepatide also imparts broad cardiovascular benefits

Medicare specifically excludes coverage for weight loss medications, though this may change as cardiovascular benefits become more established

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However, some people report other side effects, including headaches, back pain, and acid reflux

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Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, which reflect hepatocellular injury, typically decrease during GLP-1 therapy