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Earlier versions required strict timing and fasting conditions, which made adherence challenging

Lysosomal stress response (LSR): physiological importance and pathological relevance

[42] In the 1980s, scientists at University of Arizona began attempting to develop -MSH and analogs as potential sunless tanning agents, and synthesized and tested several analogs, including afamelanotide, then called melanotan-I

A deeper understanding of IR can be achieved with a more systematic approach involving large-scale omics to study the molecular landscape is of major importance in addition to exploring new intervention strategies to prevent abnormal IR syndrome

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