There is no established direct link between Mounjaro (tirzepatide) and reduced libido in clinical trials or MHRA product information
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Some research proposed that DSIP might serve a role in neuroendocrine regulation and integration of homeostatic processes
The questions that remain unanswered include the actual prevalence of sexual side effects (we do not know if it affects 5 percent or 30 percent of women), whether certain doses are more likely to cause sexual dysfunction than others, whether compounded semaglutide formulations produce different sexual side effect profiles than brand-name versions, whether specific pharmacy sources or compounding pharmacies produce formulations with different tolerability profiles, and whether pre-treatment screening can identify women at higher risk for sexual dysfunction on GLP-1 agonists
This aligns with findings from similar studies on other GLP-1 receptor agonists like semaglutide and liraglutide, which carry same boxed warning and have also not shown increased thyroid cancer rates in human populations
