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DOI: 10.1056/NEJMra2500106 4 HbA1c 2% 22% 1426% 2 GLP-1 GLP-1 NEJM 2 1 FAQ MEN2 GLP-1 2 2 BMI35BMI27 2 2BMI27 22 2 MASLD 13 GLP-1 2 GLP-1 100 STEP 1 1920 GLP-1GIP STEP 21990 John EngGLP-1-42005 STEP 3123 GLP-11GLP-1GIP2022GLP-1GIP 19 1920 Banting Best 19701980 GIP KHabenerDruckerHolstBloom GLP-1 L737 1990 John Eng -4 GLP-1GLP-1 2005 DPP-4 2010 1LEADERSUSTAIN 6 2022 GLP-1GIP GLP-1GIP3 GLP-1 GLP-1GIPDPP-44 2 DPP-4 1 GIP GIPK2GLP-1 GIPAKTGLUT4 GLP-1GIP225%3 3 3 GLP-1GIP 3 GIP K GLP-1 GLP-1GGPCRcAMPCaCaEpac2GLP-1 GIP GIPGPCRGLP-1KATPGLP-1GIPAKTBGLUT4LPL GLP-1 GLP-1 NEJM 2026 GLP-1GIPDPP-44GLP-1 GLP-1GLP-1GIP 2 2 GLP-1GIP225% 2 GLP-1 2 1426% SUSTAIN 6SOUL 3 CKD3 18% Lancet Diabetes Endocrinol 2025 FDA20251 2 20264 MACE3CVHFpEF3 LEADERSUSTAIN 6SOUL HFpEF3 522% 5,000 682.4% 723%5.39.6kg15mgtreatment estimand20.9%efficacy estimand22.5% GLP-1+GIP+2 STEP 4 GLP-1 045-864-2110 8 48%8 1.5 RCT 7610GLP-11.5 SURMOUNT-11RCT1,600 521%JAMA Netw Open 2024 EClinicalMedicine 2024 GLP-1 C GLP-1 GLP-1 FDA 2 GLP-1RA10.52mg2SOUL 2.4mg12BMI35BMI272 GLP-1+GIP 12 2025412BMI35BMI272 GLP-1RA1REWIND GLP-1RALEADER FDA20264 GLP-1RA Foundayo 202641 FDA 11 17.2mg 12% ATTAIN-1 50 FDACNPV C Boxed Warning MEN2 CNPV50 CNPVCommissioners National Priority Voucher FDA2025FDA Boxed Warning Boxed Warning FDAFoundayo C MTCMEN2 CNPV2025PMDA 23 NEJM 2026 MASLD 3N Engl J Med 2025 GLP-1 HbA1c 045-864-2110 HbA1c GLP-1 2 GLP-12026 Rosen CJ, Ingelfinger JR

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