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Treating patients with diabetes of long duration: GLP-1 receptor agonists and insulin in combination

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However, given the cardiac and renal benefits as well as the weight loss effect of GLP-1RA, the increased PRR does not mean that clinicians should restrict the use of GLP-1RA but should remain appropriate vigilance for potential adverse effects

Furthermore, GLP-1 receptor mRNA and protein have been reported in the brains of adult rodents and macaques [17]

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Here are some important interactions to be aware of: Other Antidepressants: Taking other SSRIs, tricyclic antidepressants (TCAs), or serotonin-norepinephrine reuptake inhibitors (SNRIs) with sertraline can increase the risk of serotonin syndrome