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Evaluation of the Abbott realtime HCV genotype II RUO (GT II) assay with reference to 5UTR, core and NS5B sequencing

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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918

At an optimal ratio, the combination elevated collagen IV synthesis by 25.4 times in cell models and 2.03 times in ex-vivo skin tissue compared to controls