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As a central hub for cellular energy metabolism, mitochondria not only maintain cellular homeostasis by regulating ATP production and apoptosis but also modulate immune and inflammatory responses via ATP-mediated purinergic signaling (Picca et al., 2020

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For LCMS analysis, metabolite extracts were analysed by high-resolution mass spectrometry with an Orbitrap Exploris 240 (Thermo) coupled to a Vanquish Flex liquid chromatography system (Thermo)