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The peptide N-terminus is highly conserved between GLP-1, exendin-4 and oxyntomodulin, and as such, a large number of receptor contacts are also conserved, whereas these are more divergent when compared with exendin-P5 (Supplementary Table 1)

AT expansion in obesity triggers immune cell infiltration and cytokine dysregulation, establishing a proinflammatory microenvironment that perpetuates metabolic dysfunction [185]

Within the CNS the effects of histamine binding to H 3 R include decreases in acetylcholine (ACh), serotonin and norepinephrine production and release

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doi: 10.1016/s0920-9964(96)00123-5