Gallstones (cholelithiasis)
10.1210/er.2009-0006 16 BuiA
A retrospective real-world study with an observation period of 3 months in a Chinese population with T2D shows a mean weight loss of 12.9% in patients treated with both insulin and beinaglutide without a control comparator group ( 3.1.1.2 Utreglutide (GL0034) Utreglutide is a once-weekly GLP-1 RA administered subcutaneously ( 2 at doses of 450 mcg for 4 weeks (cohort 1), 900 mcg for 4 weeks (cohort 2), and an 8-week dose escalation up to 1,520 mcg (cohort 3) ( 2 , but without T2D, a phase 1 single ascending dose (SAD) trial shows that GL0034 at doses of 1,520 mcg, 2,000 mcg, and 2,520 mcg results in mean weight loss of 2.1%, 1.9%, and 2.5%, respectively, versus 0.3% weight gain for the placebo group one week after administration ( 3.1.1.3 MET-097i MET-097i is an ultra-long acting GLP-1 RA with an elimination half-life of 380 hours ( 3.1.2 Oral 3.1.2.1 Orforglipron Orforglipron is a small molecule non-peptide oral GLP-1 RA administered once daily

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