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After these dates, compounding pharmacies could no longer rely on the drug shortage exception to justify compounding what the FDA considers "essentially a copy" of a commercially available product

As the treatment progresses and the dosage increases, the appetite-suppressing effects become stronger and more consistent

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while some licenses show no disciplinary history, others have minor citations (such as pharmacy violations and aiding unlicensed practice) that were resolved with paid fines and remain in active status

In particular for antioxidants such as vitamin C and vitamin E, high doses can cause gastrointestinal depression or other harmful effects