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Constitutive Notch2 signaling induces hepatic tumors in mice

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Tight junctions restrict paracellular diffusion, while transport proteins and efflux pumps such as ATP-binding cassette (ABC) transporters actively remove compounds entering endothelial cells

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The best effects were seen in trials that included women experiencing five or more hot flashes per day, those that used 80 mg or more of red clover isoflavones per day, those reporting higher concentrations of the isoflavone biochanin A, and those trials lasting 12 weeks or longer

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