when did glp 1 come out How GLP-1 Receptor Agonists Evolved from Diabetes to Weight Loss Treatments The GLP-1 journey: from discovery

After propensity score matching against multiple antidiabetic drug classes (insulin, metformin, SGLT-2 inhibitors, DPP-4 inhibitors, sulfonylureas), results showed: No significant increase in thyroid cancer incidence Median follow-up of ~4.5 years Risk estimates comparable or lower than other glucose-lowering therapies Overall, current epidemiological evidence does not support a clinically meaningful increase in thyroid cancer risk in humans

The Confidence Tiers We Use in This Review To keep this grounded, each item is labeled by evidence strength and real-world usefulness: Tier 1 (Strong): Consistent benefits across multiple studies and real-world use

Nature 520(7545):5762

10.1210/me.2014-1103 103 RosenstockJ.Aguilar-SalinasC.KleinE.NepalS.ListJ.ChenR.et al

Copper enhances aggregational toxicity of mutant huntingtin in a drosophila model of huntington's disease

Divalproex sodium vs placebo for the treatment of irritability in children and adolescents with autism spectrum disorders