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Higher body weight may moderately increase clearance speed, while liver disease and female biological sex extend clearance time beyond the five-hour estimate

Biochemistry 19 , 23212328 (1980)

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Note that these observations are based on case reports, and do not necessarily reflect susceptibility of these demographics to toxicity (Amar 2007)

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Given the brains dependence on a constant energy supply, any disruption in glucose or oxygen transport can lead to rapid neuronal dysfunction and cell death