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Type of reaction Enzyme Endogenous conjugating agent Examples of drugs metabolized by the same pathway Glucuronidation UDP- glucuronosyltransferase UDP-Glucoronic acid Chloramphenicol, morphine, paracetamol, salicylic acid, propofol fenoprofen, diazepam Sulfation Sulfotransferases sulfate Paracetamol, salbutamol Glycine/ glutamine conjugation JV-Acyl transferases Glycine Glutamine Cholic acid, salicylic acid, nicotinic acid, phenylacetic acid Glutathione conjugation Glutathione S transferases Glutathione Adriamycin, busulfan, chlorambucil, cis-platin, cyclophosphamide, ethacrynic acid Acetylation N- Acetyl transferases Acetyl-CoA Histamine, procainamide, sulfonamides, isoniazid, hydralazine Methylation Methyl transferase S-Adenosyl-L- methionine Morphine, norephedrine, nicotine, histamine, isoprenaline, propylthiouracil Uridine diphosphate-glucuronosyltransferases Glucuronidation is the most common and the most important conjugation reaction
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