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These properties are crucial for NP stability in biological environments and impact cell-NP interactions and subsequent uptake [73]

Laranjo, M

89 In addition to ONOO -mediated oxidation of BH 4 , there may be also an intracellular decrease because of decreased synthesis by inhibition of the GTP cyclohydrolase I ( de novo synthetic pathway) or by inhibition of the so-called salvage pathway involving enzymes such as the sepiapterin synthase, the sepiapterin reductase or the dihydrofolate reductase

References Sikiric P, Seiwerth S, Brcic L, et al