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Compounds such as alpha-chloroacetamide-based inhibitors achieve this by covalently binding to a cysteine residue in the SAM-binding pocket of NNMT 202

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More significantly, the acute application of AngIV or one of its analogs, Nle-Tyr-Ile-His-Pro-Phe (Nle 1 -AngIV), reverses deficits in dementia models induced by 1) treatment with the cholinergic muscarinic receptor antagonist scopolamine (Pederson et al., 2001), 2) kainic acid injections into the hippocampus (Stubley-Weatherly et al., 1996), 3) perforant path cuts (Wright et al., 1999), and 4) ischemia resulting from transient four-vessel occlusion (Wright et al., 1996)

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