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In pregnant rabbits given once weekly subcutaneous doses of 0.01, 0.03, or 0.1 mg/kg tirzepatide (0.01-, 0.06-, and 0.2-fold the MRHD) during organogenesis, pharmacologically-mediated effects on the gastrointestinal system resulting in maternal mortality or abortion in a few rabbits occurred at all dose levels
The function systematically omits each study one at a time from the meta-analysis and recalculates the overall effect estimate, thereby evaluating the influence of each individual study on the pooled result
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