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Category 2 : raises significant safety concerns
In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)
Dose Range: 250 mcg (0.25 mg) to 2400 mcg (2.4 mg) weekly with stepwise titration every 4 weeks to improve tolerability
The economist Alex Tabarrok has written that when an approved drug harms people there are front-page stories, but when the FDA fails to approve a good drug
This matters particularly during cold winter months when extended transit could subject peptides to temperature extremes
HR: Supervision, Writing review and editing
