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Methods Computer-aided molecular design, synthesis, and characterization All the computer-aided molecular design studies were performed in SZMAP/GamePlan 37 and vBrood 38 modules in OpenEye software and Molecular Operating Environment, MOE 39

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In connection with a reported correlation between brain ACh concentration and the inhibition of brain ChE activity following acute exposure to organophosphorus compounds, the brain tissue of three female rats per group was examined for ACh and choline concentrations

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