GRADE guidelines: 7
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16 Biomarkers of oxidative stress have been reported in many neurological and psychiatric disorders, including Alzheimer's disease, 17 Parkinson's disease, 18 schizophrenia, 19, 20 bipolar disorder 21 and alcoholism, 22 and may reflect a common underlying pathophysiological mechanism
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The number of replicates performed is detailed in each figure legend, where applicable
Additionally, its crucial to note that some antioxidant supplements have been investigated for their possible advantages in lowering oxidative stress, while the data for their efficiency is conflicting and should be reviewed with a healthcare provider ( 5 Adrenal hormonal imbalance-associated oxidative stress Adrenal hormonal imbalance-related oxidative stress is caused by dysregulation in the finely tuned endocrine system, specifically the adrenal glands ( Excess cortisol release, which is frequently associated with chronic stress, activates the glucocorticoid receptor, boosting the creation of reactive oxygen species (ROS) within cells