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Cancer drugs, genetic variation and the glutathione-S-transferase gene family

People with high levels of oxidative stress may potentially deplete their glutathione levels during the night

Authors proposed a model wherein PL enters the cell, is hydrolyzed in its active form (hPL) with subsequent formation of a hPL:GSH complex that binds the active site of GSTP1-1 causing its inhibition (Fig

After treatment, tumour volume and mass, plasma biochemistry, oxidative stress in liver and tumour, TNF- level in liver and tumour homogenates, and survival rates were analysed