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10.5483/BMBRep.2015.48.2.081 289 ShiW

The medication follows a specific titration schedule designed to minimize gastrointestinal side effects while gradually increasing therapeutic effect

Two distinct pathways lead to microbial conversion of phenylpyruvic acid to phenylacetic acid (PAA) 35

This advantage mirrors initial findings on danuglipron, another non-peptide GLP-1 agonist under development

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The single tryptophan residue also gives a usable chromophore, so concentration can be verified by UV absorbance at 280 nm where assay design requires it