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Because these mechanisms reinforce one another, the overall metabolic effect can appear robust even if any single component varies, which is another reason a clean, isolated read on the gastric-emptying contribution is so hard to obtain from combination-drug outcome data

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No head-to-head trial has compared them, so better cannot be answered directly

This concern has not been studied longitudinally even in animal models the existing preclinical studies used relatively short treatment durations

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