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As we age, our natural production of glutathione tends to decline

While exogenous antioxidants such as Nacetylcysteine (NAC), vitamins E/C, and quercetin provide critical reinforcement by scavenging residual radicals, regenerating reduced cofactors, and amplifying enzymatic antioxidant capacity through synergistic molecular interactions (Figure 3 and Table 1)

(2021) showed that oxidative stress disrupts chloride co-transporters in the hippocampus, contributing to E/I imbalances and behavioral abnormalities in ASD models

Steroids 185, 109055

These conditions destabilize phospholipid bilayers and accelerate oxidation of glutathione itself

As the number of post-mortem studies are limited, it is unclear whether these findings are true representations of regional expression variations between the hippocampus and cerebellum