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Lastly, we tested whether cells that were functionally deficient in mitochondrial ETC metabolism, owing to mutations in CI and CIV, were differentially sensitive to 5FU treatment

Clinical anti-tumor therapies that disrupt ROS homeostasis Conventional anti-tumor therapies, such as radiotherapy and chemotherapy, as well as emerging strategies such as photodynamic therapy, aim to deliberately increase ROS levels to selectively target and eliminate cancer cells

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Cao X, Zheng S, Zhang S, et al

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