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By analyzing serum neuron-derived EVs, the study further explored how exenatide may modify brain insulin signaling pathways

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Exendin 939 directly binds to the TRPV1 channel To assess the direct interaction between exendin 939 and the TRPV1 channel, we conducted a protein binding assay using His-tagged exendin 939, which was able to pull down the TRPV1 channel (Fig