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Altered hepatic foci in rat liver as weight of evidence of carcinogenicity: The Canadian perspective

For comparison, the FDA's 2003 guidance on pharmacokinetics in patients with impaired hepatic function recommends that drugs primarily cleared by the liver undergo dedicated studies across Child-Pugh categories A, B, and C [9]

Chembiochem (2022) 23(10):e202100641

These advanced in vitro systems are crucial for validating the complex interplay between genetic risk, viral mechanisms, and cell pathology identified in epidemiological studies, moving beyond correlational data to establish a causal mechanism