insomnia and semaglutide Insomnia: Why You Feel "Wired" & How to Fix It – Som Sleep Can Wegovy Cause Insomnia? Sleep

[Wadden STEP 3, JAMA 2021] STEP 5 Trial (Nature Medicine 2022) Long-term data: patients maintained an average 15.2% weight loss over 2 years of continuous semaglutide use, with sustained metabolic improvements including reduced HbA1c, blood pressure, and waist circumference

Strengths Short-term analyses, such as ours, have several advantages over long-term analyses

GLP-1s can induce side effects like nausea, diarrhea, or headaches

However, semaglutide does delay gastric emptying, which could theoretically affect absorption of oral medications, though UK product information indicates no clinically relevant effect for most oral medicines

This is particularly relevant for women with irregular menstrual cycles, PCOS, or other reproductive conditions, and for men with known semen abnormalities

This potential side effect may also be a good reminder that Ozempic is inappropriate for people who do not have a good medical reason to lose weight