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Discussion Despite recent advancements in cardiovascular prevention and treatment, cardiovascular disease remains the leading cause of death worldwide, particularly among high-risk populations such as those with type 2 diabetes and/or hypertension [1]

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The associated SNP, rs10305420, is a missense variant in the signal peptide of the GLP1R gene, changing the seventh amino acid from proline to leucine (p.Pro7Leu)

Mol Cell Endocrinol (2015) 418 Pt 1:4254

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