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Clinical Takeaways As the prevalence of obesity, insulin resistance, metabolic syndrome and associated health complications continue to rise, targeting GLP-1 activity has emerged as a promising strategy in improving cardiometabolic health and encouraging sustainable weight loss

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For instance, mitoDFO impairs ironsulfur cluster and heme biosynthesis [147], while glycyrrhetinic acid (GA) and pyrrolo[3,2-d]pyrimidine derivatives inhibit one-carbon metabolism [148,149,150]