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The reduction in hepatic fat in HIV-associated fatty liver disease, alongside the primary visceral-fat effect, has been characterized in randomized trials, and the mechanistic follow-up identified reductions in fibro-inflammatory mediators (VEGFA, TGF-1, CSF1) that track with improvements in liver-injury scores

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Quercetin, a plant flavonoid commonly used for immune and antioxidant support

TRPV1 modulation also indirectly influences melanogenesis and the production of protective pigments like melanin, which can shield against UV-induced oxidative damage 160

These groups received intravenous treatments of PBS, oridonin, orid-liposome, orid-liposome-MAL, TLR2 pep-orid-liposome at a dose of 5 mg/kg, or PBS as control every other day