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The execution of ferroptosis involves complex regulation of multiple metabolic pathways (Figure 1), including disruptions in iron homeostasis, abnormalities in amino acid antioxidant systems, and the accumulation of lipid peroxides (Zheng et al., 2025

A Scoping Review

Bioavailability is the key to unlocking these benefits

These factors should be taken into consideration in future studies

Fer-1 liposome eye drops can inhibit corneal opacity and increase bioavailability fivefold in a rabbit corneal alkali burn model, which indicates that agents that target ferroptosis have the potential for clinical translation and the treatment of ocular diseases

Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes