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Supplementation with 600 mg/day of vitamin E did not show differences with respect to the placebo group (Galbussera et al., 2006)

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EHMT2/G9a stood out as a potential target: it is an epigenetic regulator expressed in immune cells, including macrophages, and its previously determined half maximal effective concentration (EC 50 ) (PubChem AID: 504332) matches the effect range (10100 M) seen in our study 39

Acknowledgements This work was supported by the National Nature Science Foundation of China (No

Further, they found that key proteins involved in ferroptosis regulation had abnormal expression in the villous tissue (VT) of TP patients, and that lipid oxidation was activated markedly