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Marcus's protocol was a daily subcutaneous injection administered at bedtime

The production of intrinsic factor happens in the stomach, which if impaired, can have a hard time properly synthesizing this protein

Riboflavin deficiency may be associated with an increased risk of anemia during pregnancy, and RCTs conducted in pregnant populations have demonstrated that the inclusion of riboflavin with other micronutrient supplements (namely iron and folic acid) leads to greater improvements in hematological parameters, such as hemoglobin concentration, RBC count, and anemia prevalence (reviewed in 62)

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Reference MedlinePlus Cyanocobalamin Injection: Drug Information

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