The TCA cycle Following pyruvate entry into the mitochondria, pyruvate is metabolized in the TCA cycle to generate NADH and FADH2 to fuel the electron transport chain but also metabolic intermediates for biosynthesis and NADPH production
2019;370:87693 Zhao P, Qiu L, Zhou S, Li L, Qian Z, Zhang H
Thank them for extracting relevant GWAS summary-level data from published articles, UK Biobank, and Human blood metabolites analyzed
Myelin protects nerve fibers
Its proposed mechanisms involve multiple cytoprotective pathways including upregulation of VEGF and growth factors promoting angiogenesis, modulation of the nitric oxide system, activation of the FAK-paxillin pathway for cell migration and tissue repair, interaction with the gut-brain axis affecting dopaminergic and serotonergic systems, and gastroprotective effects against NSAID and alcohol-induced mucosal damage
R01DK127800, R01DK090625, R01DK132647, R01DK142852, and P30DK020595, and National Institute on Aging (NIA) grant nos