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(iii) gain of function mutations in the PIK3CA gene, encoding the catalytic subunit of human PI3K

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Nifedipine A single-dose, metformin-nifedipine drug interaction study in normal healthy volunteers demonstrated that co-administration of nifedipine increased plasma metformin C max and AUC by 20% and 9%, respectively, and increased the amount excreted in the urine