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While likely safer than long-acting systemic analogs, IGF-1 DES is not without risks

The molecules, which Bowers and Momany referred to as GH releasing peptides (GHRPs), were generated by the chemical modification of met-enkephalin and included growth hormone releasing peptide (GHRP)-6, GHRP-2, and hexarelin [45]

That short window is actually the point it produces discrete, pulsatile GH release that more closely mirrors natural secretion patterns

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