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Phase 2 Published 2023 The New England Journal of Medicine The most-cited medical journal in the world Jastreboff et al., 2023 338 adults with obesity, randomized to placebo or one of four Retatrutide doses (1, 4, 8, 12 mg weekly)
However, access challenges related to cost and insurance coverage may limit equitable distribution of these therapies ^19
Patients may use medications as a standalone treatment or as a bridge to other interventions
The use of peptide dual agonists of the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R) is one of the treatment options being researched and evaluated clinically for diabetes, obesity, and related conditions
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