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A deficiency in vitamin B12 can cause fatigue, headaches, indigestion, problems with your vision, increased risk of obesity, and cognitive difficulties
By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1)
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[1] Selectivity testing indicated the scaffold did not inhibit related SAM-dependent methyltransferases or NAD+ salvage enzymes
In short, while B12 corrects deficiency reliably, it does not act like a weight-loss drug in people with normal levels
MIC B12 injections work best when combined with these efforts
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